Bartender Doc Hendley is providing clean water to communities worldwide. Through creative fundraising, his nonprofit Wine to Water has brought sustainable water systems to 25,000 people in five countries.

Breast cancer survivor Andrea Ivory is bringing early detection to the doorsteps of uninsured women. With mobile mammography vans, her group has provided more than 500 free screenings in Miami, Florida.

Zimbabwe native Betty Makoni founded the Girl Child Network to provide a haven for young victims of sexual abuse. The organization has rescued more than 35,000 girls since 2001.

School bus driver Jorge Munoz is helping hungry New Yorkers make it through tough times. Since 2004, he has handed out more than 70,000 meals from his mobile soup kitchen in Queens—for free.

Efren Peñaflorida gives Filipino youth an alternative to gang membership through education. His Dynamic Teen Company's 10,000 members have taught basic reading and writing to 1,500 kids living in the slums.

Budi Soehardi founded a children's home in one of the poorest areas of Indonesia. Today, Roslin Orphanage in West Timor provides food, shelter and education to more than 45 children.

Derrick Tabb started The Roots of Music to give young people an alternative to New Orleans' streets. His music education program provides free tutoring, instruments and music instruction to more than 100 students.

Jordan Thomas, 20, of Chattanooga, Tennessee, lost both his legs in a boating accident in 2005. Since then, his Jordan Thomas Foundation has raised more than $400,000 to provide prosthetics for children in need.