Bea Alonzo is Jackie Madrigal-Roxas. As the unica hija of a banking magnate, Jackie is the exact opposite of Eli in terms of status. She is now married to Eli but there are people around her who do not want her to get her happy ending.

Anne Curtis is Celine Magsaysay, a strong girl who faces every trial in her life head on. She presents a tough image for everyone to see, but in reality she carries a sadness that she cannot seem to let go. Hidden behind her image of steel is actually a heart of gold.

Sam Milby is JB Berenguer, a man who has everything, except his freedom. He is the heir apparent to the Roxas Shipping empire, which is now under the helm of his mother, Corazon (Chin-Chin Gutierrez). He wants to help his mother so she could be proud of him. JB and Celine have vowed to not let go of the love they once lost but is love enough tp bond them together? What will happen if fate intervenes in their relationship?

Angelica Panganiban plays Maria Lena Rubio Madrigal, the half-sister of Jackie (Bea Alonzo). They have the same father, Don Fidel Madrigal, portrayed by Christopher de Leon.

Her mother Veronica (played by Rosanna Roces) is a mistress of the Madrigal patriarch.

The mysterious Joaquin Delos Santos is played by Derek Ramsey, the real-life boyfriend of Angelica Panganiban.

Pinoy Big Brother host Toni Gonzaga stars in her first drama series as Onay Dimaano. Her character is tired of waiting for the ever elusive special someone. In real life, Toni is happily committed to her boyfriend, Paul Soriano, a renowned director.

Christopher de Leon is the wealthy banking magnate Don Fidel Madrigal. He is the father of Jackie and Lena, whom he sired with different women.

Thinking that he is cheated by the women in his life (his mother, also Imelda's mother, his wife, his daughter), he becomes very bitter towards life. He is willing to risk everything he has to achieve the peace he has been seeking for years.

Chin-Chin Gutierrez is Corazon Roxas-Berenguer, JB's mother. She is the matriarch of the Roxas family and oversees their shipping company. She has a dark past that gives her a hateful outlook in life, but in her is a pure heart screaming to be freed.

Phillip Salvador is added to Maging Sino Ka Man Book 2 as Samuel Mateo Romualdez, Eli's biological father who has a lot of angst in his life.

Rosanna Roces is Veronica Rubio. She is the mistress of Don Fidel (Christopher de Leon) and the mother of Lena (Angelica Panganiban). She desires to exact revenge on those who persecuted her in the past.