Cynthia Lennon has died, aged 75.
The artist—who was married to The Beatles musician John Lennon from 1962 until 1968—passed away at her home in Spain, a statement on the website of the couple's son, Julian Lennon, has confirmed.
The message read: "Cynthia Lennon passed away today at her home in Mallorca, Spain following a short but brave battle with cancer.
"Her son Julian Lennon was at her bedside throughout. The family are thankful for your prayers.
"Please respect their privacy at this difficult time."
Cynthia, who was formerly known by her maiden name Powell, met John in the 1960s at a calligraphy class at Liverpool College of Art, before they married and had their only child together in 1963.
However, the couple separated in 1968 when he left her for artist Yoko Ono, after which she married twice more, before separating from her third husband, engineer John Twist, in 1983.
After the separation and John's death in 1980, she changed her name back to Lennon, although was later married nightclub owner Noel Charles from 2002 until he died in 2013.
During her life, Cynthia wrote two books about her ill-fated relationship with the iconic musician: A Twist of Lennon in 1980, and John, which was released in 2005.
TRIBUTES. Yoko Ono and Sir Paul McCartney have led tributes to Cynthia.
The 82-year-old Japanese star praised the late artist for being a "wonderful mother" to her and the Beatles star's 51-year-old son Julian Lennon.
In a statement, the singer and activist said: "I'm very saddened by Cynthia's death. She was a great person and a wonderful mother to Julian.
"She had such a strong zest for life and I felt proud how we two women stood firm in the Beatles family.
"Please join me in sending love and support to Julian at this very sad time."
John and Cynthia separated in 1968 after he left her for Yoko, whom he was married to until his death in 1980.
Former Beatles star Paul, 72, also posted a touching message about Cynthia on his website, writing: "The news of Cynthia's passing is very sad. She was a lovely lady who I've known since our early days together in Liverpool. She was a good mother to Julian and will be missed by us all, but I will always have great memories of our times together."
His bandmate Ringo Starr, 74, sent his best to Julian via Twitter, writing: "Peace and love to Julian Lennon. God bless Cynthia love Ringo and Barbara xx."